Low frequency of alterations of the α (PPP2R1A) and β (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms
✍ Scribed by Calin, George A; di Iasio, Maria Grazia; Caprini, Elisabetta; Vorechovsky, Igor; Natali, Pier Giorgio; Sozzi, Gabriella; Croce, Carlo M; Barbanti-Brodano, Giuseppe; Russo, Giandomenico; Negrini, Massimo
- Book ID
- 110062735
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 241 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Mutations of the __PPP2R1B__ gene, which encodes the Aβ scaffolding subunit of serine/threonine protein phosphatase 2A (PP2A), have been identified in several types of cancer including lung and breast carcinoma. One of these mutations results in an alteration of glycine 90 to aspartic a
Protein phosphatase 2A (PP2A) consists of 3 subunits: the catalytic subunit, C, and the regulatory subunits, A and B. The A and C subunits both exist as 2 isoforms (␣ and ) and the B subunit as multiple forms subdivided into 3 families, B, B and B؆. It has been reported that the genes encoding the