The zona pellucida: A coat of many colors
β Scribed by Paul M. Wassarman
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 831 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
β¦ Synopsis
The zona pellucida is an extracellular coat that surrounds all mammalian eggs. It is a porous matrix of interconnected filaments that are assembled from glycoproteins synthesized and secreted by growing oocytes. The zona pellucida is responsible both for species-specific binding of sperm to unfertilized eggs and inducing bound sperm to undergo the acrosome reaction. The latter enables sperm to penetrate the extracellular coat and fertilize the egg. The zona pellucida also a i h in prevention of polyspermy following fertilization and in protection of preimplantation embryos. In mice, several of these important functions can
now be ascribed to specific zona pellucida glycoproteins that have been purified and characterized. Furthermore, the enzyme responsible for hatching of embryos from the zona pellucida, just prior to implantation, has been ident$ed and characterized.
π SIMILAR VOLUMES
The zona pellucida is a thick extracellular coat that surrounds all mammalian eggs and preimplantation embryos. The zona pellucida supports communication between oocytes and follicle cells during oogenesis; protects oocytes, eggs, and embryos during development, and regulates interactions between ov
Sheep eggs were obtained at appointed times from 4 to 16 hours after ovulation and examined for evidence of penetration by spermatozoa. The following observations were made: ( 1 ) The fertilizing spermatozoon makes a curved slit in the zona as a result of traversing it. The slit seems to be an open
## Abstract The proteolytic action of boar sperm acrosin on its natural substrate, the zona pellucida, was investigated. Acrosin exhibited substrate specificity for the zona pellucida and differentially hydrolyzed the glycoprotein families composing the zona pellucida. In contrast to acrosin, tryps
Boar sperm acrosin was previously shown to hydrolyze the porcine zona pellucida in a specific and limited fashion. The action of acrosin on its presumed physiological substrate was investigated further in terms of the hydrolysis products formed. Peptide mapping experiments of zona pellucida glycopro
## Abstract IAM38 is the most prominent protein of the inner acrosomal membrane extracellular coat (IAMC) of spermatozoa. It is retained by the inner acrosomal membrane after the acrosome reaction and is implicated in secondary spermβzona binding (Yu et al., Dev Biol2006;290:32β43). Its gene knocko