𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The zona pellucida: A coat of many colors

✍ Scribed by Paul M. Wassarman


Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
831 KB
Volume
6
Category
Article
ISSN
0265-9247

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✦ Synopsis


The zona pellucida is an extracellular coat that surrounds all mammalian eggs. It is a porous matrix of interconnected filaments that are assembled from glycoproteins synthesized and secreted by growing oocytes. The zona pellucida is responsible both for species-specific binding of sperm to unfertilized eggs and inducing bound sperm to undergo the acrosome reaction. The latter enables sperm to penetrate the extracellular coat and fertilize the egg. The zona pellucida also a i h in prevention of polyspermy following fertilization and in protection of preimplantation embryos. In mice, several of these important functions can

now be ascribed to specific zona pellucida glycoproteins that have been purified and characterized. Furthermore, the enzyme responsible for hatching of embryos from the zona pellucida, just prior to implantation, has been ident$ed and characterized.


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