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Structure and function of the mammalian egg zona pellucida

✍ Scribed by Wassarman, Paul; Chen, Jie; Cohen, Natalie; Litscher, Eveline; Liu, Chengyu; Qi, Huayu; Williams, Zev

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 794 KB
Volume: 285
Category: Article
ISSN: 0022-104X
DOI: 10.1002/(sici)1097-010x(19991015)285:3<251::aid-jez8>3.0.co;2-1

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✦ Synopsis

The zona pellucida is a thick extracellular coat that surrounds all mammalian eggs and preimplantation embryos. The zona pellucida supports communication between oocytes and follicle cells during oogenesis; protects oocytes, eggs, and embryos during development, and regulates interactions between ovulated eggs and free-swimming sperm during and following fertilization. Mutant females that produce eggs that lack a zona pellucida are infertile. The functions of the zona pellucida during fertilization now can be ascribed to certain of its glycoproteins. Here we describe some aspects of zona pellucida structure and function as they relate to mammalian fertilization.

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