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The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway

✍ Scribed by Thiefes, Axel; Wolf, Alexander; Doerrie, Anneke; A Grassl, Guntram; Matsumoto, Kunihiro; Autenrieth, Ingo; Bohn, Erwin; Sakurai, Hiroaki; Niedenthal, Rainer; Resch, Klaus; Kracht, Michael


Book ID
110033099
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
201 KB
Volume
7
Category
Article
ISSN
1469-221X

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πŸ“œ SIMILAR VOLUMES


TAB2, a Novel Adaptor Protein, Mediates
✍ Giichi Takaesu; Satoshi Kishida; Atsushi Hiyama; Kyoko Yamaguchi; Hiroshi Shibuy πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 English βš– 382 KB

The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negativ