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The Wnt/beta-catenin pathway is activated during advanced arterial aging in humans

✍ Scribed by Alexandre Marchand; Fabrice Atassi; Amira Gaaya; Pascal Leprince; Claude Le Feuvre; Florent Soubrier; Anne-Marie Lompré; Sophie Nadaud

Book ID
111199716
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
604 KB
Volume
10
Category
Article
ISSN
1474-9718

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## Abstract The Wnt/β‐catenin signaling pathway is inactivated by Wnt antagonists in most cancers and IGFBP‐4 is an antagonist of the Wnt/ β‐catenin signaling pathway. However, the function of IGFBP‐4 is not currently understood in renal cell carcinoma (RCC). We initially found that the expression