The von Hippel–Lindau Tumor Suppressor Gene
✍ Scribed by Keiichi Kondo; William G. Kaelin Jr.
- Book ID
- 115603928
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 85 KB
- Volume
- 264
- Category
- Article
- ISSN
- 0014-4827
No coin nor oath required. For personal study only.
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## Abstract Deletions of the short arm of chromosome 3 are often observed in a specific subset of aggressive neuroblastomas (NBs) with loss of distal 11q and without __MYCN__ amplification. The critical deleted region encompasses the locus of the von Hippel‐Lindau gene (__VHL__, 3p25). Constitution
## Abstract Hypoxia–inducible factor (HIF) remains the central focus of oxygen sensing during hypoxia. HIF is a heterodimeric transcription factor consisting of an oxygen‐regulated alpha‐ and a constitutively expressed beta subunit. The von Hippel‐Lindau tumor suppressor (pVHL) is a component of th