The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis
โ Scribed by Schoenfeld, Alan R; Parris, Tchaiko; Eisenberger, Andrew; Davidowitz, Eliot J; Leon, Maryely De; Talasazan, Faranaz; Devarajan, Prasad; Burk, Robert D
- Book ID
- 110064297
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 272 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0950-9232
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๐ SIMILAR VOLUMES
Communicated by Victor A. McKusick von Hippel-Lindau disease (VHL) is an inherited neoplastic disorder characterized by the development of tumors in the eyes, brain, spinal cord, inner ear, adrenal gland, pancreas, kidney, and epididymis. The VHL tumor suppressor gene was identified in 1993. Initial
## Abstract Deletions of the short arm of chromosome 3 are often observed in a specific subset of aggressive neuroblastomas (NBs) with loss of distal 11q and without __MYCN__ amplification. The critical deleted region encompasses the locus of the von HippelโLindau gene (__VHL__, 3p25). Constitution