✦ LIBER ✦

The value of maintenance therapy following treatment of central nervous system leukemia

✍ Scribed by Elaine Morgan; Milton H. Donaldson; Anna T. Meadows

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 354 KB
Volume: 40
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(197709)40:3<1005::aid-cncr2820400307>3.0.co;2-1

No coin nor oath required. For personal study only.

✦ Synopsis

The efficacy of intrathecal (IT) maintenance chemotherapy following central nervous system (CNS) leukemia was demonstrated in a retrospective study of 77 such episodes. The median durations of CNS and bone marrow (BM) remissions were significantly longer for the 41 maintained episodes (10+ and 9.5 months, respectively) compared with the 36 unmaintained episodes (4 and 2 months, respectively). Patients were comparable in each of these two groups. For those patients receiving maintenance therapy, there appeared to be an advantage in using four or more doses of IT medications for treatment of CNS leukemia, regardless of the number of doses necessary to clear the cerebrospinal fluid (CSF).

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