## Abstract Parkinson's disease (PD) patients show a range of executive deficits involving dopaminergic transmission in the prefrontal cortex. In this study, we have investigated the impact of catecholโOโmethylโtransferase (COMT) val^158^met polymorphisms on performance of the Tower of London (TOL)
โฆ LIBER โฆ
The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease
โ Scribed by J.B. Rowe; L. Hughes; C.H. Williams-Gray; S. Bishop; S. Fallon; R.A. Barker; A.M. Owen
- Book ID
- 116781373
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 348 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0197-4580
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## Abstract ## Background: The Aโallele of the catecholโ__O__โmethyltransferase (__COMT__) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. ## Methods: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent t
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