The usual suspects: tyrosine hydroxylase and the serotonin transporter in affective disorders
โ Scribed by Collier, D A; Sham, P C
- Book ID
- 110058899
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 30 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1359-4184
No coin nor oath required. For personal study only.
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## Abstract Family, twin, and adoption studies show that psychiatric diseases including bipolar disorder (BP) and unipolar disorder (UP) have a substantial genetic component. For these illnesses, both positive and negative associations have been reported for two polymorphisms located in the seroton
Tyrosine hydroxylase (TH) is the ratelimiting enzyme in the synthesis of dopamine and noradrenaline. While positive associations between TH and bipolar affective disorder have been found in several studies, many studies have failed to reproduce these results. In order to clarify this situation, asso
Tyrosine hydroxylase is the rate-limiting step in the biosynthesis of catecholamines. To find variants in the tyrosine hydroxylase (TH) gene that are associated with schizophrenia, mood disorders, or alcohol dependence, all of the exons, the exon-intron boundaries, and the 5 promoter region of the T