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The use of the polymerase chain reaction to analyze HLA class II sequence polymorphism and genetic susceptibility to myasthenia gravis

✍ Scribed by Begovich, A.B.; Oksenberg, J.R.; Griffith, R.L.; Steinman, L.; Erlich, H.A.


Book ID
123097281
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
67 KB
Volume
23
Category
Article
ISSN
0198-8859

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Objective. In Northern Europeans, rheumatoid arthritis (RA) is strongly associated with a relatively conserved pentapeptide sequence of HLA-DRP found notably in the HLA-DR4 subtypes Dw4 and Dw14 and in DRl. A previous serologic study of HLA class I1 polymorphism in a Greek population with RA failed