𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The Use of Proton Chemical Shifts to Define the Solution Structure of a Dimeric Peptide

✍ Scribed by Bernard Busetta; Philippe Picard

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
559 KB
Volume
2
Category
Article
ISSN
1075-2617

No coin nor oath required. For personal study only.

✦ Synopsis

For flexible peptides, nuclear Overhauser Effects (NOE) experiments do not provide enough information to ensure a correct definition of their solution structure. The use of distance constraints, derived from the knowledge of proton chemical shifts, is developed to restrict the number of possible conformations. In the case of flexible molecules, randomization appears as an important factor of the correct estimation of the chemical shifts from the 3D structure. The refinement of the solution structure of the highly flexible AVP-like parallel dimer is described to illustrate this process.

πŸ“œ SIMILAR VOLUMES

The use of Ξ³-turn mimetics to define pep
The use of Ξ³-turn mimetics to define peptide secondary structure
✍ James F. Callahan; Kenneth A. Newlander; Joelle L. Burgess; Drake S. Eggleston; πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 French βš– 803 KB

A novel ytum mimetic 2 has been prepared based on retro amide peptide design Incorporation of this mimetic into linear peptidejibritwgen receptor antagonist 7 (GPlIWIUa receptor) @rds the opportunity to test models of antagonist pharmacophore.

The13C chemical shifts of amino acids in
The13C chemical shifts of amino acids in aqueous solution containing organic solvents: Application to the secondary structure characterization of peptides in aqueous trifluoroethanol solution
✍ Venkataraman Thanabal; Diana O. Omecinsky; Michael D. Reily; Wayne L. Cody πŸ“‚ Article πŸ“… 1994 πŸ› Springer Netherlands 🌐 English βš– 819 KB

The 13C chemical shifts for all of the protonated carbons of the 20 common amino acid residues in the protected linear pentapeptide Gly-Gly-X-Gly-Gly have been obtained in water at low pH as well as in aqueous solution containing 10, 20 and 30% acetonitrile or trifluoroethanol. Dioxane was used as a