𝔖 Bobbio Scriptorium
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The use of monoclonal antibodies against thyroglobulin in immunoperoxidase techniques

✍ Scribed by W. Ormanns; R. Schäffer

Publisher
Springer
Year
1983
Tongue
English
Weight
977 KB
Volume
78
Category
Article
ISSN
1432-119X

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✦ Synopsis

A monoclonal mouse antibody to human thyroglobulin was used in a modified biotin-peroxidase-complex method to demonstrate thyroglobulin in different tissues and tumors of the thyroid gland. Mouse ascites fluid containing monoclonal antibodies could be diluted up to 1:1,600 for detection of thyroglobulin, whereas no staining was observed in a medullary carcinoma. Nonspecific background staining was negligible. These results demonstrate that monoclonal antibodies against thyroglobulin are suitable in the immunohistochemicat localisation of thyroid hormones.

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