✦ LIBER ✦

The immunohistochemical demonstration of thyroglobulin in human thyroid tumour xenografts using a monoclonal antibody

✍ Scribed by T. C. Richardson; S. A. Humm; T. E. F. Carr

Publisher: Springer
Year: 1987
Tongue: English
Weight: 780 KB
Volume: 86
Category: Article
ISSN: 1432-119X
DOI: 10.1007/bf00495007

No coin nor oath required. For personal study only.

✦ Synopsis

A monoclonal antibody (RBU/01) was raised against human thyroglobulin and its suitability for the immunohistochemical staining of thyroglobulin was determined on fixed, wax-embedded tissue, using the peroxidase anti-peroxidase (PAP) method. The antibody was then used to demonstrate the expression of human thyroglobulin in sections of a human follicular carcinoma of the thyroid which had been grown in immunodeficient mice. It is concluded that the immunohistochemical evaluation of the xenografts with the antibody provides useful information on this xenograft system as a potential model for thyroid carcinoma.

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