✦ LIBER ✦

The use of in vitro cell culture models for mechanistic studies and as permeability screens for the blood–brain barrier in the pharmaceutical industry—Background and current status in the drug discovery process

✍ Scribed by Stefan Lundquist; Mila Renftel

Book ID: 114413474
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 675 KB
Volume: 38
Category: Article
ISSN: 1537-1891
DOI: 10.1016/s1537-1891(02)00203-3

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Progress and limitations in the use of i

Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier

✍ Mark Gumbleton; Kenneth L. Audus 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 200 KB 👁 1 views

A relatively simple, widely applicable, and robust in vitro method of predicting blood-brain barrier (BBB) permeability to central nervous system-acting drugs is an increasing need. A cell-based model offers the potential to account for transcellular and paracellular drug diffusional processes, meta

Primary cultures of brain microvessel en

Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood–brain barrier in vitro

✍ Helmut Franke; Hans-Joachim Galla; Carsten T Beuckmann 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 233 KB

[Biotechnology: Pharmaceutical Aspects]

[Biotechnology: Pharmaceutical Aspects] Drug Absorption Studies Volume VII || Cell Culture Models of the Corneal Epithelium and Reconstructed Cornea Equivalents for In Vitro Drug Absorption Studies

✍ Ehrhardt, Carsten; Kim, Kwang-Jin 📂 Article 📅 2008 🏛 Springer US ⚖ 207 KB

Usefulness and limitation of primary cul

Usefulness and limitation of primary cultured porcine choroid plexus epithelial cells as an in vitro model to study drug transport at the blood–CSF barrier

✍ Susanne Angelow; Patrick Zeni; Hans-Joachim Galla 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 686 KB

Comparison of immortalized bEnd5 and pri

Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood–brain barrier models for the study of T cell extravasation

✍ Steiner, Oliver; Coisne, Caroline; Engelhardt, Britta; Lyck, Ruth 📂 Article 📅 2010 🏛 Nature Publishing Group 🌐 English ⚖ 698 KB

Evaluation of bEnd5 cell line as an in v

Evaluation of bEnd5 cell line as an in vitro model for the blood–brain barrier under normal and hypoxic/aglycemic conditions

✍ Yang, Tianzhi (author);Roder, Karen E. (author);Abbruscato, Thomas J. (author) 📂 Article 📅 2007 🏛 John Wiley and Sons Inc. 🌐 English ⚖ 478 KB 👁 2 views

The purpose of the study was to assess the suitability of the mouse endothelial cell line bEnd5 as a blood-brain barrier (BBB) model under normal or pathologic (stroke) conditions. In comparison to the well-established bovine brain endothelial cell (BBMEC) model, cultured bEnd5 monolayers reached a