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Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood–brain barrier models for the study of T cell extravasation

✍ Scribed by Steiner, Oliver; Coisne, Caroline; Engelhardt, Britta; Lyck, Ruth


Book ID
109871622
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
698 KB
Volume
31
Category
Article
ISSN
0271-678X

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✍ Yang, Tianzhi (author);Roder, Karen E. (author);Abbruscato, Thomas J. (author) 📂 Article 📅 2007 🏛 John Wiley and Sons Inc. 🌐 English ⚖ 478 KB 👁 2 views

The purpose of the study was to assess the suitability of the mouse endothelial cell line bEnd5 as a blood-brain barrier (BBB) model under normal or pathologic (stroke) conditions. In comparison to the well-established bovine brain endothelial cell (BBMEC) model, cultured bEnd5 monolayers reached a