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The use of hybridoma cells as a murine model to study tumor immunity

✍ Scribed by Taichi Ezaki; John Marbrook

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
476 KB
Volume
35
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The secretion of antibody by hybridoma cells allows the growth of individual cells to be measured by a hemolytic plaque assay. Similarly, plaque reduction assays are sensitive indicators of tumor immunity. A series of strains of hybridoma have been isolated from an original isolate which is sensitive to cytotoxic T cells and NK cells. In the derivation of a spleen‐seeking variant, the cells appear to have lost immunogenic but not antigenic characteristics. This model lends itself to the quantitative study of immune constraints on tumor growth in vivo. Combined with the selection of tumor variants, the model is of wide application to many fields of tumor biology, particularly where sensitive measurement of tumor cell number and viability is crucial.

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