From the determination of the Michaehs-Menten kinetic parameters (V, and Km) of renal tubular secretion of D-( -)p-n-propylmandelic acid (V) and D-( -)-p-isopropylmandelic acid (VI) in rats, it is shown that these compounds involve the same renal tubular carrier for their secretion but the affinity
โฆ LIBER โฆ
The use of generalized Michaelis-Menten kinetics to measure sensitivity in gastric acid secretion
โ Scribed by J.Wanzer Drane; Charles T. Richardson
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 567 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0010-4809
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Whenever hydrogen bonding is involved in molecular recognition, the possibility of a proton transfer from the donor to the acceptor arises. In most cases the pK a of the donor is far enough above the pK a of the conjugate acid of the acceptor for it to be clear that no proton transfer will occur. Ho