✦ LIBER ✦
Michaelis—menten kinetic parameters of renal tubular secretion of para-alkylated mandelic acids and their use in revealing possible chemical characteristics around receptor site of secretion carrier in rats
✍ Scribed by Janardan B. Nagwekar; Pravin M. Patel; Moiz A. Khambati
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 698 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
From the determination of the Michaehs-Menten kinetic parameters (V, and Km) of renal tubular secretion of D-( -)p-n-propylmandelic acid (V) and D-( -)-p-isopropylmandelic acid (VI) in rats, it is shown that these compounds involve the same renal tubular carrier for their secretion but the affinity of V for the carrier is approximately twice that of VI. By considering these parameters as well as the structural variations of V and VI, to-