✦ LIBER ✦

The use of atypical antipsychotics in the treatment of schizophrenia in North Staffordshire

✍ Scribed by Richard Hodgson; R. Belgamwar; Yasin Al-tawarah; G. MacKenzie

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 95 KB
Volume: 20
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.669

No coin nor oath required. For personal study only.

✦ Synopsis

Aims:

To examine the long-term effectiveness of atypical antipsychotics in a naturalistic setting for patients with schizophrenia.

Method:

A retrospective analysis of atypical antipsychotic prescribing in one health district between 1994 and 2001. time to discontinuation of the first atypical antipsychotic prescribed was calculated using survival analysis.

Results:

253 patients were identified. clozapine had a significantly lower discontinuation rate compared with olanzapine and risperidone (p = 0.018). patients taking risperidone were 1.3 times more likely to discontinue than those taking olanzapine (p = 0.23). older age (p = 0.0001), male sex (p = 0.016) and exposure to antidepressants (p = 0.014) significantly predicted compliance.

Conclusions:

Clozapine is an effective long-term schizophrenia treatment. the trend to superior effectiveness of olanzapine over risperidone in the long-term has not been reported before and warrants further investigation.

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