✦ LIBER ✦

Citalopram augmentation of antipsychotic treatment in older schizophrenia patients

✍ Scribed by John W. Kasckow; Somaia Mohamed; Arthur Thallasinos; Brendan Carroll; Sidney Zisook; Dilip V. Jeste

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 54 KB
Volume: 16
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.508

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Depressive symptoms are common in older patients with schizophrenia; yet, few studies have examined the usefulness of antidepressants in this population.

Objective

We conducted a 10‐week single‐blind trial of citalopram (20–40 mg/day) vs no citalopram augmentation in 19 middle‐aged and elderly patients with schizophrenia hospitalized for more than six of the last 12 months. At study‐entry, the patients had been on stable doses of antipsychotics for at least two weeks, and had a 17‐item Hamilton Depression Rating (HAM‐D) scale score of 12 or greater. Nine patients were randomly assigned to citalopram augmentation, and 10 to no augmentation of antipsychotics.

Results

Patients in both groups improved on positive and negative symptoms, but the citalopram group had significantly greater improvement in HAM‐D and Clinical Global Impression Scale scores than the control group. There were no major side effects.

Conclusion

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