✦ LIBER ✦

The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling

✍ Scribed by Francesco Blasi; Nicolai Sidenius

Book ID: 113621784
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 407 KB
Volume: 584
Category: Article
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2009.12.039

No coin nor oath required. For personal study only.

✦ Synopsis

uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that over‐expression of components of the uPA/uPAR‐system correlates with increased proliferation, migration, and invasion affecting the malignant phenotype of cancer. uPAR regulates the cells–extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade.

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