The urokinase receptor. A cell surface, regulated chemokine
β Scribed by FRANCESCO BLASI
- Book ID
- 111277894
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 569 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0365-5555
No coin nor oath required. For personal study only.
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Urokinase and its receptor are essential components of the cell migration machinery, providing an inducible, transient and localized cell surface proteolytic activity. This activity has been shown to be required in normal and pathological forms of cellular invasiveness (i.e. in several embryonic dev
uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that overβexpression of components of the uPA/uPARβsystem correlates with increased prolifer