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The upregulation of dihydropyrimidine dehydrogenase in liver is involved in acquired resistance to 5-fluorouracil

✍ Scribed by Li, Long-Hao; Dong, Hang; Zhao, Feng; Tang, Jie; Chen, Xin; Ding, Jing; Men, Hai-Tao; Luo, Wu-Xia; Du, Yang; Ge, Jun; Tan, Ben-Xu; Cao, Dan; Liu, Ji-Yan

Book ID: 123038783
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 690 KB
Volume: 49
Category: Article
ISSN: 0959-8049
DOI: 10.1016/j.ejca.2012.12.013

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## Abstract Defects in apoptosis have been implicated in chemoresistance of colon cancer cells. We report here the ability to resist to 5‐fluorouracil‐induced apoptosis of 8 colon cancer cell lines differing in __p53__ and __bax__ status: p53^−/0^bax^+/+^ for TC7, SW480, HT‐29; p53^+/+^bax^−/−^ for