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Long-term persistence of acquired resistance to 5-fluorouracil in the colon cancer cell line SW620

✍ Scribed by I.K. Tentes; W.M. Schmidt; G. Krupitza; G.G. Steger; W. Mikulits; A. Kortsaris; R.M. Mader

Book ID
113956054
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
959 KB
Volume
316
Category
Article
ISSN
0014-4827

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## Abstract Defects in apoptosis have been implicated in chemoresistance of colon cancer cells. We report here the ability to resist to 5‐fluorouracil‐induced apoptosis of 8 colon cancer cell lines differing in __p53__ and __bax__ status: p53^βˆ’/0^bax^+/+^ for TC7, SW480, HT‐29; p53^+/+^bax^βˆ’/βˆ’^ for