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The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

✍ Scribed by Michela Guglielmotto; Manuela Aragno; Riccardo Autelli; Luca Giliberto; Erica Novo; Sebastiano Colombatto; Oliviero Danni; Maurizio Parola; Mark A. Smith; George Perry; Elena Tamagno; Massimo Tabaton


Book ID
111181264
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
968 KB
Volume
108
Category
Article
ISSN
0022-3042

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## Abstract Poly(ADP‐ribose) polymerase‐1 (PARP‐1) is a nuclear protein that, once activated by genotoxic agents, modulates the activity of several nuclear proteins including itself. Previous studies have established that PARP‐1 inhibition may provide benefit in the treatment of different diseases,