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Regulation of malignant progression by the hypoxia-sensitive transcription factors HIF-1α and MTF-1

✍ Scribed by Brian J. Murphy

Book ID
116345974
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
357 KB
Volume
139
Category
Article
ISSN
1096-4959

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## Abstract Using oligonucleotide expression microarrays we have examined the modulation of gene expression in the DU145 prostate cancer cell line. Our findings confirm that the Egr1 transcription factor is rapidly and transiently upregulated by hypoxia. Furthermore, we have demonstrated that HIF‐1