𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The universal validity of the possible triangle constraint for affected sib pairs

✍ Scribed by Zeny Z. Feng; Jiahua Chen; Mary E. Thompson


Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
830 KB
Volume
33
Category
Article
ISSN
0319-5724

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


The β€œpossible triangle” test for extreme
✍ Rita Kruse; Susanne A. Seuchter; Max P. Baur; Michael Knapp πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 91 KB

For the analysis of quantitative traits in nuclear families, extreme discordant sib pairs proved to be more powerful than unselected sib pairs. Here, we present a test that makes use of selected pairs and, in addition, restricts the parameters of the identical-by-descent distribution analogously to

Power of the affected-sib-pair method fo
✍ Lynn R. Goldin; Elliot S. Gershon; I. B. Borecki πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 505 KB

We have examined the sample sizes required to detect linkage using the affectedsib-pair (ASP) method for major psychiatric disorders that are characterized by population prevalences of 1-7 % , decreased penetrance, phenocopies, and heterogeneity. In addition, the nature of these illnesses makes larg

Two-stage global search designs for link
✍ Xiuqing Guo; Robert C. Elston πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 72 KB πŸ‘ 3 views

Two-stage global search designs for linkage analysis using pairs of affected relatives were shown by Elston et al. [1996] to typically halve the cost of a study compared to a one-stage design. The statistic used for testing linkage in that study was based on the proportion of pairs sharing no marker

Power comparison of generalizations of t
✍ Michael Knapp πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 129 KB πŸ‘ 1 views

## Abstract Previously applied test statistics for affected sib pairs (ASP) have been criticized for not fully exploiting the power of a given sample, because they do not account for incomplete informativity of an affected sib pair. To circumvent this problem, recently a new test had been proposed

A genome-wide linkage analysis for the p
✍ Po-Hsiu Kuo; Michael C. Neale; Brien P. Riley; Diana G. Patterson; Dermot Walsh; πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 225 KB πŸ‘ 2 views

## Abstract Neuroticism is a personality trait which reflects individual differences in emotional stability and vulnerability to stress and anxiety. Consistent evidence shows substantial genetic influences on variation in this trait. The present study seeks to identify regions containing susceptibi

Comparison of four sib-pair linkage meth
✍ Laurent Abel; Alexandre Alcais; Alain Mallet πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 205 KB πŸ‘ 2 views

Family samples collected for sib-pair linkage studies usually include some sibships with more than two affecteds (multiplex sibships). Several methods have been proposed to take into account these multiplex sibships, and four of them are discussed in this work. Two methods, which are the most widely