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The “possible triangle” test for extreme discordant sib pairs

✍ Scribed by Rita Kruse; Susanne A. Seuchter; Max P. Baur; Michael Knapp

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
91 KB
Volume
14
Category
Article
ISSN
0741-0395

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✦ Synopsis

For the analysis of quantitative traits in nuclear families, extreme discordant sib pairs proved to be more powerful than unselected sib pairs. Here, we present a test that makes use of selected pairs and, in addition, restricts the parameters of the identical-by-descent distribution analogously to the "possible triangle" for affected sib pairs. In the Problem 2A data, extreme discordant sib pairs are selected. The analysis allowed the detection of most simulated major genes.

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