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The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis

✍ Scribed by S. A. Mousavi; K. E. Berge; T. P. Leren

Book ID
108863694
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
223 KB
Volume
266
Category
Article
ISSN
0954-6820

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## Abstract Proprotein convertase subtilisin/kexin type 9 (PCSK9) induces degradation of low‐density lipoprotein receptor (LDLR) in the liver. It is being pursued as a therapeutic target for LDL‐cholesterol reduction. Earlier genome‐wide gene expression studies showed that PCSK9 over‐expression in