Proprotein convertase subtilisin/kexin type 9 potentially influences cholesterol uptake in macrophages and reverse cholesterol transport
β Scribed by Shen, Li; Peng, Hong-chun; Nees, Shannon N.; Zhao, Shui-ping; Xu, Dan-yan
- Book ID
- 120354542
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 240 KB
- Volume
- 587
- Category
- Article
- ISSN
- 0014-5793
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## Abstract Proprotein convertase subtilisin/kexin type 9 (PCSK9) induces degradation of lowβdensity lipoprotein receptor (LDLR) in the liver. It is being pursued as a therapeutic target for LDLβcholesterol reduction. Earlier genomeβwide gene expression studies showed that PCSK9 overβexpression in
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