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The unique characteristics of Thai Leber hereditary optic neuropathy: analysis of 30 G11778A pedigrees

โœ Scribed by Nopasak Phasukkijwatana; Wanicha L. Chuenkongkaew; Rungnapa Suphavilai; Bhoom Suktitipat; Sarinee Pingsuthiwong; Ngamkae Ruangvaravate; La-ongsri Atchaneeyasakul; Sukhuma Warrasak; Anuchit Poonyathalang; Thanyachai Sura; Patcharee Lertrit

Book ID
106252101
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
219 KB
Volume
51
Category
Article
ISSN
1435-232X

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๐Ÿ“œ SIMILAR VOLUMES

Leber hereditary optic neuropathy: Does
Leber hereditary optic neuropathy: Does heteroplasmy influence the inheritance and expression of the G11778A mitochondrial DNA mutation?
โœ Chinnery, Patrick F. ;Andrews, Richard M. ;Turnbull, Douglass M. ;Howell, Neil ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 209 KB ๐Ÿ‘ 2 views

Leber hereditary optic neuropathy (LHON) is a major cause of inherited blindness in young males. Approximately 1 in 7 individuals with LHON harbor a mixture of mutated and wild-type (normal) mtDNA (heteroplasmy), and the risks of developing blindness in heteroplasmic LHON individuals are not well ch

Detection of the G to A mitochondrial DN
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โœ B. A. Kormann; H. Schuster; T. A. Berninger; B. Leo-Kottler ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 342 KB

Leber's hereditary optic neuropathy (LHON) is characterized by acute or subacute bilateral (usually permanent) loss of central vision, caused by neuroretinal degeneration. The maternal inheritance is explained by the mitochondrial origin of the disease. Recently, a single mitochondrial DNA (mtDNA) m