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The ubiquitin/proteasome system-dependent control of mitochondrial steps in apoptosis

✍ Scribed by Neutzner, Albert; Li, Sunan; Xu, Shan; Karbowski, Mariusz

Book ID
119366919
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
620 KB
Volume
23
Category
Article
ISSN
1084-9521

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## Abstract The lysosomal apoptosis pathway is a potentially interesting therapeutic target. Since apoptosis involving the lysosomal pathway has been described to involve cathepsins, we screened a drug library for agents that induce cathepsin‐dependent apoptosis. Using pharmacological inhibitors an