The two β-oxidation sites in pea cotyledons
✍ Scribed by D. R. Thomas; C. Wood
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 556 KB
- Volume
- 168
- Category
- Article
- ISSN
- 0032-0935
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✦ Synopsis
Two sites for β-oxidation of fatty acids in pea (Pisum sativum L.) cotyledons exist. One site is the microbody, the other the mitochondrion. Mitochondrial β-oxidation of fatty acids is carnitine-dependent. The fatty acid permeates the membrane as palmitoylcarnitine which is formed from cytosolic-side palmitoyl-CoA by a carnitine palmitoyltransferase located on the exterior face of the inner mitochondrial membrane as a peripheral protein. A single-gated pore integral membrane translocator is proposed to exchange the palmitoylcarnitine for carnitine or acetylcarnitine across the membrane. An internal (matrix side) carnitine palmitoyltransferase then reforms palmitoyl-CoA which enters β-oxidation and subsequently the tricarboxylic-acid cycle.
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