## Abstract Chemotherapy is an important therapeutic approach for cancer treatment. However, drug resistance is an obstacle that often impairs the successful use of chemotherapies. Therefore, overcoming drug resistance would lead to better therapeutic outcomes for cancer patients. Recently, studies
The two faces of PTP1B in cancer
β Scribed by Laurent Lessard; Matthew Stuible; Michel L. Tremblay
- Book ID
- 103823609
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 306 KB
- Volume
- 1804
- Category
- Article
- ISSN
- 1570-9639
No coin nor oath required. For personal study only.
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Intracellular levels of proteinβphosphotyrosine are regulated by the proteinβtyrosine phosphatase (PTP) family. Cellular compartmentalization may play an important role in modulating the function of these enzymes. The recent demonstration that PTPβ1B is localized to the endoplasmic reti
As in other fields of biomedical research, the use of gene-targeted mice by homologous recombination in embryonic stem cells has provided important findings on the function of several members of the protein tyrosine phosphatase (PTP) family. For instance, the phenotypic characterization of knockout