Differential intracellular compartmentalization of phosphotyrosine phosphatases in a glial cell line: TC-PTP versus PTP-1B
✍ Scribed by Dr. Robert Faure; Barry I. Posner
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 417 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0894-1491
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✦ Synopsis
Abstract
Intracellular levels of protein‐phosphotyrosine are regulated by the protein‐tyrosine phosphatase (PTP) family. Cellular compartmentalization may play an important role in modulating the function of these enzymes. The recent demonstration that PTP‐1B is localized to the endoplasmic reticulum (Frangioni et al: Cell 68:545, 1992) is consistent with this proposition. In this study we have examined the intracellular distribution of TC‐PTP in a glial cell line (C6). Using indirect immunofluorescence we have shown that this enzyme is distributed differently from PTP‐1B and is mainly concentrated in the perinuclear region of these cells. © 1993 Wiley‐Liss, Inc.