The tumour-localizing properties of porphyrin derivatives

✍ Scribed by S. Nakajima; H. Hayashi; Y. Omote; Y. Yamazaki; S. Hirata; T. Maeda; Y. Kubo; T. Takemura; Y. Kakiuchi; Y. Shindo; K. Koshimizu; I. Sakata

• Book ID: 103993130
• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 577 KB
• Volume: 7
• Category: Article
• ISSN: 1011-1344
• DOI: 10.1016/1011-1344(90)85156-q

✦ Synopsis

The tumour-localizing abilities of various kinds of porphyrin derivatives in tumour-bearing hamsters were assessed by nitrogen-pulsed laser spectrofluorometry (N2-PLS). On examination of porphine derivatives (from haemoglobin), it was found that the dimer and acetylated and amidated compounds had a high affinity for tumour tissue; the dimer and hydroxylated compound of phorbine derivatives (from chlorophyll) also showed a high affinity. Furthermore, of the metalloporphines (gallium, zinc and indium complexes), those which contained hydrophilic groups showed a high affinity for tumour tissue; of the metallophorbines (gallium, zinc and indium complexes), those which contained hydrophobic groups showed a high affinity. A correlation was found between the side-chain structure of the porphyrins and metalloporphyrins and their affinity for tumour tissue.