The tumor suppressor p53 modifies mutational processes in a human lymphoblastoid cell line
β Scribed by Fen Xia; Howard L Liber
- Book ID
- 114071123
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 251 KB
- Volume
- 373
- Category
- Article
- ISSN
- 0027-5107
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In this study, we analyzed 10 human squamous cell carcinomas (SCCs) for alterations in the p53 tumor suppressor gene in exons 4 through 9 by single-strand conformation polymorphism (SSCP) analysis. We found that 2 of 10 SCCs displayed unusual SSCP alleles at exon 7 of the p53 gene. Subsequent clonin
Communicated by
## Abstract A variety of neoplasms of the human nervous system were analyzed for the presence of mutations in the __p53__ tumor suppressor gene. DNA was extracted from frozen or formalinβfixed, paraffinβembedded material. Singleβstrand conformation polymorphism (SSCP) analysis for exons 5β8 was fol
p53 is upregulated in the majority of spontaneous tumors and the HLA class I molecule HLA-A2 is expressed by approximately 50% of the caucasians. Potentially, these facts make HLA-A2-binding p53 peptides for CTL-inducing immunotherapy applicable to a broad range of cancer patients. In our study, we