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The Tritope Model for restrictive recognition of antigen by T-cells: II. Implications for ontogeny, evolution and physiology

✍ Scribed by Melvin Cohn

Book ID: 116755840
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 549 KB
Volume: 45
Category: Article
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2006.02.033

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## Abstract TCR degeneracy may facilitate self‐reactive T cell activation and the initiation of an autoimmune response in multiple sclerosis (MS). MHC class II alleles of the DR2 haplotype DR2a (DRB5\*0101) and DR2b (DRB1\*1501) are associated with an increased risk for MS in Caucasian populations.