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T-cell antigen recognition and costimulatory pathways: implications for the induction of transplantation tolerance

✍ Scribed by M Suthanthiran

Book ID: 117229361
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 61 KB
Volume: 32
Category: Article
ISSN: 0041-1345
DOI: 10.1016/s0041-1345(00)01287-2

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## Abstract Steady‐state dendritic cells (DC) present peptide‐MHC complexes to T cells in a tolerogenic manner, presumably because of deficient costimulation. However, it is clear that the path to tolerance involves initial T cell activation, suggesting that the deficit may lie in late‐acting costi