✦ LIBER ✦

The trigeminovascular system in bacterial meningitis

✍ Scribed by Olaf Hoffmann; Ulrich Dirnagl; Joerg R. Weber

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 88 KB
Volume: 53
Category: Article
ISSN: 1059-910X
DOI: 10.1002/jemt.1083

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✦ Synopsis

Abstract

Headache as a cardinal symptom of acute meningitis reflects activation of trigeminal afferents from the meninges. With their perivascular endings, these fibers form the so‐called trigeminovascular system (TVS), which releases proinflammatory neuropeptides upon nociceptive stimulation. In the present article, we review a role of the TVS in enhancing the early inflammatory response of bacterial meningitis. Furthermore, we discuss inhibition of neuropeptide release from the TVS using 5HT~1B/D~ agonists as a potential new anti‐inflammatory treatment strategy for early bacterial meningitis. Microsc. Res. Tech. 53:188–192, 2001. © 2001 Wiley‐Liss, Inc.

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