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The transforming growth factor β signaling pathway in endometrial cancer: Expression and clinical significance

✍ Scribed by J. Kesterson; D. Wang; S. Akers; N. duPont; K. Clark; S. Lele; S. Liu; P. Mhawech-Fauceglia

Book ID
113962953
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
51 KB
Volume
120
Category
Article
ISSN
0090-8258

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## Abstract Transforming growth factor‐β (TGF‐β) family members are polypeptides with dual tumor suppressive and oncogenic effects. They signal through serine/threonine kinase receptor complexes, which phosphorylate cytoplasmic mediators, the Smads. Upon phosphorylation, Smads translocate to the nu