The transcriptional role of Smads and FAST (FoxH1) in TGFβ and activin signalling
✍ Scribed by Liliana Attisano; Cristoforo Silvestri; Luisa Izzi; Etienne Labbé
- Book ID
- 117462789
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 138 KB
- Volume
- 180
- Category
- Article
- ISSN
- 0303-7207
No coin nor oath required. For personal study only.
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## Abstract Transforming growth factor‐β (TGF‐β) signaling is known to depend on the formation of Smad2/3‐Smad4 transcription regulatory complexes. However, the signaling functions of Smad2/3‐Smad4 during TGF‐β‐induced responses are obscure as TGF‐β also initiates a number of other signaling pathwa
## Abstract Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells, and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. Smad2 and Smad3 are direct mediators of TGF‐β signaling, however little is kno