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The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells

✍ Scribed by Koji Murao; Hitomi Imachi; Xiao Yu; Tomie Muraoka; Naohisa Hosami; Hiroaki Dobashi; Toshihiko Ishida


Book ID
118422541
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
423 KB
Volume
207
Category
Article
ISSN
0021-9150

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## Abstract Transcription factor Ets‐1 is induced in endothelial cells (ECs) by angiogenic factors, and promotes angiogenesis by inducing angiogenesis‐related genes such as MMPs and integrin β3. Here, we examined the effect of Ets‐1 on apoptosis in ECs. Overexpression of Ets‐1 in human umbilical ve