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The transcription-repression domain of the adenovirus E1A oncoprotein targets p300 at the promoter

✍ Scribed by Green, M; Panesar, N K; Loewenstein, P M

Book ID: 109970879
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 327 KB
Volume: 27
Category: Article
ISSN: 0950-9232
DOI: 10.1038/onc.2008.85

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## Abstract The use of adenovirus serotype 2 or 5 (Ad2/5) E1A as therapy for human malignancy requires an understanding of the mechanisms involved in E1A‐induced tumor suppression. The prevailing use of E1A in the treatment of human malignancy stresses the non‐immunologically mediated, anti‐tumorig