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The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

✍ Scribed by Susanne M. Pritchard; Philip J. Dolan; Alisa Vitkus; Gail V.W. Johnson

Book ID
114778919
Publisher
Carol Davila University of Medicine Bucharest, Romania
Year
2011
Tongue
English
Weight
810 KB
Volume
15
Category
Article
ISSN
1582-1838

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## Abstract Alzheimer's disease (AD) is a dementing neurodegenerative disorder without a cure. The abnormal parenchymal accumulation of β‐amyloid (AΞ²) is associated with inflammatory reactions involving microglia and astrocytes. Increased levels of AΞ² and AΞ² deposition in the brain are thought to c