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The Total Synthesis of Tubulysin D (I).

✍ Scribed by Hillary M. Peltier; Jeffrey P. McMahon; Andrew W. Patterson; Jonathan A. Ellman

Publisher
John Wiley and Sons
Year
2007
Weight
15 KB
Volume
38
Category
Article
ISSN
0931-7597

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Tubulysins (1) are compounds of extraordinary potency, rapidly degrading the tubulin cytoskeleton, with tubulysin D being the most active tubulin-modifier known so far. [1,2] The tubulysins were first described by HΓΆfle, Reichenbach, and co-workers in 2000. [3,4] Several representatives are active w

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