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The total synthesis of the natural product endothelin converting enzyme (ECE) inhibitor, WS75624 B

✍ Scribed by William C. Patt; Mark A. Massa


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
172 KB
Volume
38
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


ChemInform Abstract: The Total Synthesis
✍ W. C. PATT; M. A. MASSA πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 2 views

The Total Synthesis of the Natural Product Endothelin Converting Enzyme (ECE) Inhibitor, WS75624 B. -Starting from commercially available kojic acid (I), the first total synthesis of racemic (XIII) is reported. The racemate and a natural sample of WS75624 B show identical activity against the ECE en

Total synthesis of endothelin-converting
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A concise synthesis of endothelin-converting enzyme antagonist WS75624 B is reported. The natural product was prepared in seven steps from 2,4-dibromothiazole.

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