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ChemInform Abstract: The Total Synthesis of the Natural Product Endothelin Converting Enzyme (ECE) Inhibitor, WS75624 B.

✍ Scribed by W. C. PATT; M. A. MASSA

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199724257

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✦ Synopsis

The Total Synthesis of the Natural Product Endothelin Converting Enzyme (ECE) Inhibitor, WS75624 B. -Starting from commercially available kojic acid (I), the first total synthesis of racemic (XIII) is reported. The racemate and a natural sample of WS75624 B show identical activity against the ECE enzyme. -(

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