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ChemInform Abstract: Synthesis of Novel Substituted Pyridines as Inhibitors of Endothelin Converting Enzyme-1 (ECE-1).

โœ Scribed by M. A. MASSA; W. C. PATT; K. AHN; A. M. SISNEROS; S. B. HERMAN; A. DOHERTY


Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
30
Category
Article
ISSN
0931-7597

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ChemInform Abstract: The Total Synthesis
โœ W. C. PATT; M. A. MASSA ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB ๐Ÿ‘ 1 views

The Total Synthesis of the Natural Product Endothelin Converting Enzyme (ECE) Inhibitor, WS75624 B. -Starting from commercially available kojic acid (I), the first total synthesis of racemic (XIII) is reported. The racemate and a natural sample of WS75624 B show identical activity against the ECE en